– Oncology – High saturated fat diet linked to postop biochemical failure

From MedWire News

Among prostatectomy patients, those with diets high in high saturated fat (HSF) are almost twice as likely to experience biochemical failure as those who consume a low saturated fat (LSF) diet, say US scientists.
Several studies have indicated that obesity is associated with an increased risk of biochemical failure after treatment with radical prostatectomy or external beam radiation for localized prostate cancer.

Patients at risk of prostate cancer and thosewith prostate cancer should reduce their fat intake.

Prostate Cancer: Obese men are more likely to have worse pathology reports than expected

Dr. Koop – Biopsy Underestimates Prostate Cancer in Overweight Men:

beige_quote.bmpResearchers compared the biopsy grade to the cancer grade following radical prostatectomy, which is the removal of the prostate. In 1,113 men who underwent radical prostatectomy between 1996 and 2005 within the Shared Equal Access Regional Cancer Hospital database, 299 men, or 27 percent, had more severe cancer than suggested by biopsy. In 123 patients, or 11 percent, cancer diagnosis was actually less severe.

This was an interesting study that concluded that obesity is one of the risk factors for upgrading at the time of pathological analysis.
The last time I reviewed my database I found that 30% of my gleason 6 cancers were upgraded to 7. I have not done an analysis to see which patients are more at risk yet.

Obese patients at higher risk during surgery

Straightfromthedoc: Risk of Post-Operative Complications, Higher in Obese Patients:

Morbidly obese patients had a death rate nearly twice as high as that of all other patients, had higher rate of cardiac arrest and have significantly higher risk of complications following surgery, including heart attack, wound infection, nerve injury and urinary tract infection.
Such were the findings of a new study of a research team at the University of Michigan Health System.

Bamgbade and the other researchers found much higher rates of the following complications in obese patients: heart attack, with obese patients experiencing five times the rate of attack than non-obese patients (0.5 percent versus 0.1 percent); wound infection, with a 1.7-times higher rate (6 percent versus 3.5 percent); peripheral nerve injury, with a four-times higher rate (0.4 percent versus 0.1 percent); and urinary tract infection, with a 1.5-times higher rate (3.9 percent versus 2.6 percent).

This is another study that confirms that obese patients are at increased risk during surgery. I think minimally invasive and robotic surgery has the greatest benefit on obese patients.

Loosing weight may help prevent prostate cancer

Study ties weight loss to prostate cancer risk | Chicago Tribune
Study ties weight loss to prostate cancer risk
By Daniel Yee
Associated Press
Published December 27, 2006
“”ATLANTA — A new study has found that losing weight reduces the risk of an aggressive form of prostate cancer.
After tracking the weight of nearly 70,000 men between 1982 and 1992, researchers from the American Cancer Society and the Duke University Prostate Center found that men who lost more than 11 pounds had a lower risk for aggressive prostate cancer than men whose weight remained the same over a decade.””
Multiple studies have shown that obese men have higher risks of more aggressive prostate cancer. This study shows that men may lower their risk of developing aggressive prostate cancer by loosing weight.
Men should also remember that their risk of dying from heart disease is usually higher than their risk of dying from prostate cancer after they have been diagnosed with cancer.
I also think that things that prevent prostate cancer may slow down recurrent cancer.

Obesity and prostate cancer

UroToday – Obesity, Diabetes, and Risk of Prostate Cancer: Results from the Prostate Cancer Prevention Trial: “These unique data obtained from a prospective randomized trial suggest that obesity may preferentially increase the risk of high-grade prostate cancer, while decreasing the risk of developing low-grade tumors. The authors suggest that this may explain why no association between BMI and prostate cancer has been found in studies that have not subdivided patients based on Gleason score.”
Original Abstract: Cancer Epidemiol Biomarkers Prev. 2006 Oct;15(10):1977-83
Obesity is considered by most to be a risk factor. This study showed a higher risk of more aggressive prostate cancer, but a lower risk of low grade prostate cancer in obese patients.
This study was taken from the prostate cancer prevention trial, where patients were followed for 7 years to determine the effects of proscar on the prevention of prostate cancer. This database of over 10,000 patients should provide many studies in the future.