Prostate Cancer Risk Lower in Men Who Ejaculate More – Renal and Urology News

The protective effect of frequent intercourse is strongest for low-risk prostate cancer.

An ejaculation frequency of 21 or more times per month at age 20–29 years and 40–49 years is associated with a significant 19% and 22% decreased risk of a PCa diagnosis, respectively, compared with a frequency of 4–7 times per month in adjusted analyses, Jennifer R. Rider, MD, of the Boston University School of Public Health, and colleagues reported. In addition, results showed that ejaculation frequency at age 20–29 years was significantly associated with intermediate-risk PCa. Men in this age group who had 13 or more ejaculations per month experienced a significant 27% reduction in the risk of a diagnosis of intermediate-risk PCa compared with those who had 4–7 ejaculations per month. Ejaculation frequency was not significantly associated with a diagnosis of high-risk PCa or regional/distant metastases, according to the investigators.

Source: Prostate Cancer Risk Lower in Men Who Ejaculate More – Renal and Urology News

Men often ask me about the effects of sexual activity on prostate cancer. This study shows that more frequent relations help prevent prostate cancer.  The amount of activity needed to have this benefit seems high to me.  Being active more than 2 of 3 days is much more than most men are currently experiencing.

I will need to add this to the list of things I tell men about how to stay healthy.

Green Tea May Inhibit Prostate Cancer Tumor Growth – Renal and Urology News

Drinking green tea may play a role in the inhibition of prostate cancer tumor growth, according to a study presented at the American Association for Cancer Research’s International Conference on Frontiers in Cancer Prevention Research in Anaheim, Calif.

via Green Tea May Inhibit Prostate Cancer Tumor Growth – Renal and Urology News.

Green tea is one of the drinks that I think is helpful for men with prostate cancer.  This study showed intracellular changes seen in prostate cancer cells in men that were drinking it.

FDA committee votes down 5-ARIs for prostate cancer risk reduction – – UrologyTimes

“Although the REDUCE trial demonstrated a risk reduction in a large number of men, the committee chose to focus on a small number of high-grade cancers and determined that this class of drugs is inappropriate for prostate cancer risk reduction, even in the population of men with elevated PSA and previous negative biopsy,” added Dr. Gomella, a co-investigator of the REDUCE trial. “This decision will certainly reduce the enthusiasm for further large-scale, long-term studies of any prostate cancer chemoprevention or risk-reduction strategy.”

via FDA committee votes down 5-ARIs for prostate cancer risk reduction – – UrologyTimes.

This was a disappointing study for me.  Medications such as avodart and proscar have been shown to reduce the risk of prostate cancer.  Early studies revealing a higher percentage of high grade cancers have existed.  These studies were based on biopsy specimens only, which often understage cancer.

Other studies that looked at patients who had removal of the prostate have not revealed a higher incidence of high grade cancers in patients on these medicines.

I will inform patients that the FDA did not approve the indication of prostate cancer reduction for avodart and proscar (finasteride).  I think may patients will still opt for the medication.  Patients with large prostates will also have the benefit of a reduction in BPH symptoms.


Dr Moyad on Vitamin E- Do not take over 400 IU daily

Source: Dr. Moyad on December 2008 Newsletter

“It is now 100% official, high-doses (400 IU or more per day) of vitamin E supplements should not be taken by anyone, especially men trying to prevent, those diagnosed, or even treated for prostate cancer (in other words all men on planet earth)!!!”

Dr. Moyad is in my opinion, the most respected and knowledgeable authority on nutritional support and supplements for prostate cancer. He comments on how the use of high dose Vitamin E is not only beneficial, but likely harmful.

SELECT: Selenium, vitamin E show no benefit in prostate cancer prevention – – UrologyTimes

Source: Urology Times

Selenium and vitamin E supplements, taken either alone or together, do not appear to prevent prostate cancer, according to an initial, independent review of study data from the Selenium and Vitamin E Cancer Prevention Trial (SELECT).
The data also showed two concerning trends: a small but not statistically significant increase in the number of prostate cancer cases among the more than 35,000 men age 50 years and older in the trial taking only vitamin E; and a small, but not statistically significant increase in the number of cases of adult-onset diabetes in men taking only selenium.
Because this is an early analysis of the data from the study, neither of these findings proves an increased risk from the supplements, and both may be due to chance, according to the authors.

This was a well recruited study that started many years ago when I was at Indiana. We were one of the sites that were recruiting patients. This is the first analysis I have seen from this, so we will need to wait for more data to come out. According to early findings, neither Vitamin E nor selenium help prevent prostate cancer.

A recipe for pomegranate dip

Recipe for Healthy Living: Pomegranate dip – The Cancer Blog: “Here is an unusual dip for breads, pita, or a variety of dipping chips. I like to eat this by dipping vegetables into it, especially jicama which is mild in flavor and doesn’t over power the dip.
Vicki’s Pomegranate Yogurt Dip
1 large pomegranate
2 cups chilled plain yogurt
3 tablespoons of chives
1/4 cup pomegranate juice
1/3 cup finely chopped fresh cilantro
1/2 teaspoon salt
1/4 teaspoon black pepper”
I found a recipe to add pomegranate into your diet on the cancer blog.
The only thing about pomegranate juice is that it is loaded with sugar. It is probably more harmful than good for diabetic patients and can contribute to weight gain. If you add pomegranate juice to your diet, keep an eye on your calorie intake.

Celebrex and Green tea

UroToday – Green Tea and COX-2 Inhibitors Combine to Slow Growth of Prostate

BERKELEY, CA ( – Drinking a nice warm cup of green tea has
long been touted for its healthful benefits, both real and anecdotal.
But now researchers have found that a component of green tea, combined
with low doses of a COX-2 inhibitor, could slow the spread of human
prostate cancer.

In the March 1 issue of Clinical Cancer Research, researchers from
University of Wisconsin-Madison demonstrate that low doses of the COX-2
inhibitor celecoxib, administered with a green tea polyphenol called
pigallocatechin-3-gallate (EGCG), can slow the growth of human prostate
cancer. Their experiments were performed in cell cultures and in a mouse
model for the disease.

Weight, Weight Loss and the Risk of Prostate Cancer

Body Mass Index, Weight Change, and Risk of Prostate Cancer in the Cancer Prevention Study II Nutrition Cohort
Written by Ricardo Sanchez-Ortiz, MD
Thursday, 15 February 2007
BERKELEY, CA ( – In the last five years, a large body of evidence has been accumulated supporting the association between obesity and high-risk prostate cancer.
Despite this advancement in our knowledge of prostate carcinogenesis, the exact interplay between BMI and patient risk remains poorly understood.
In the January issue of Cancer Epidemiology, Biomarkers, Rodríguez and colleagues from the American Cancer Society report data from the Cancer Prevention Study II Nutrition Cohort evaluating the relationship between obesity and prostate cancer risk. Beside its large size, this study is newsworthy because it substratified prostate cancer patients based on tumor grade and stage.

Read More

Loosing weight may help prevent prostate cancer

Study ties weight loss to prostate cancer risk | Chicago Tribune
Study ties weight loss to prostate cancer risk
By Daniel Yee
Associated Press
Published December 27, 2006
“”ATLANTA — A new study has found that losing weight reduces the risk of an aggressive form of prostate cancer.
After tracking the weight of nearly 70,000 men between 1982 and 1992, researchers from the American Cancer Society and the Duke University Prostate Center found that men who lost more than 11 pounds had a lower risk for aggressive prostate cancer than men whose weight remained the same over a decade.””
Multiple studies have shown that obese men have higher risks of more aggressive prostate cancer. This study shows that men may lower their risk of developing aggressive prostate cancer by loosing weight.
Men should also remember that their risk of dying from heart disease is usually higher than their risk of dying from prostate cancer after they have been diagnosed with cancer.
I also think that things that prevent prostate cancer may slow down recurrent cancer.

Obesity and prostate cancer

UroToday – Obesity, Diabetes, and Risk of Prostate Cancer: Results from the Prostate Cancer Prevention Trial: “These unique data obtained from a prospective randomized trial suggest that obesity may preferentially increase the risk of high-grade prostate cancer, while decreasing the risk of developing low-grade tumors. The authors suggest that this may explain why no association between BMI and prostate cancer has been found in studies that have not subdivided patients based on Gleason score.”
Original Abstract: Cancer Epidemiol Biomarkers Prev. 2006 Oct;15(10):1977-83
Obesity is considered by most to be a risk factor. This study showed a higher risk of more aggressive prostate cancer, but a lower risk of low grade prostate cancer in obese patients.
This study was taken from the prostate cancer prevention trial, where patients were followed for 7 years to determine the effects of proscar on the prevention of prostate cancer. This database of over 10,000 patients should provide many studies in the future.

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